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Article

The combined effects of the BDNF and GSK3B genes modulate the relationship between negative life events and major depressive disorder.

Brain research - 8 Oct 2010

Yang Chunxia, Xu Yong, Sun Ning, Ren Yan, Liu Zhifen, Cao Xiaohua, Zhang Kerang

Abstract excerpt

For major depressive disorder (MDD), BDNF and GSK3B are logical candidate genes and an interaction between BDNF polymorphism and negative life events has been observed. Our previous study revealed that a gene-gene interaction among BDNF and GSK3B may confer the risk of MDD. In the present study, we hypothesized a gene-environment interaction between the BDNF-GSK3B combination and negative life events in the risk...

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Source

Identifiers

PMID: 20682308
DOI: 10.1016/j.brainres.2010.07.079

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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