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Article

Interaction of tryptophan hydroxylase 2 gene and life events in susceptibility to major depression in a Chinese Han population.

Journal of affective disorders - 1 Dec 2015

Ma Jingsong, Xiao Hai, Yang Yanjie, Cao Depin, Wang Lin, Yang Xiuxian, Qiu Xiaohui, Qiao Zhengxue, Song Junyao, Liu Yuexi, Wang Peng, Zhou Jiawei, Zhu Xiongzhao

Abstract excerpt

BACKGROUND: Major depression (MD) results from a complex synergy between genetic and environmental factors. The aim of this study is to analyze the interaction of tryptophan hydroxylase 2 gene (TPH2) variation and negative life events in the pathogenesis of MD. Three TPH2 polymorphisms, -703G/T (rs4570625), -473T/A (rs11178997), and 1463G/A (rs120074175), were selected based on previous findings of associations...

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Source

Identifiers

PMID: 26386440
DOI: 10.1016/j.jad.2015.07.041

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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