Article
GNB3 and CREB1 gene polymorphisms combined with negative life events increase susceptibility to major depression in a Chinese Han population.
PloS one - 1 Jan 2017
Ma Jingsong, Wang Lin, Yang Yanjie, Qiao Zhengxue, Fang Deyu, Qiu Xiaohui, Yang Xiuxian, Zhu Xiongzhao, He Jincai, Pan Hui, Ban Bo, Zhao Yan, Sui Hong
Abstract excerpt
BACKGROUND: Major depression (MD) is caused by a combination of genetic and environmental factors. In this study we investigated the interaction of variations in the G-protein beta 3 subunit (GNB3) and cAMP response element binding protein 1 (CREB1) genes with negative life events in the pathogenesis of MD. One GNB3 polymorphism (rs5443) and four CREB1 polymorphisms (rs2253206, rs2551941, rs6740584, rs11904814)...