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Article

Role of DNA methylation in miR-200c/141 cluster silencing in invasive breast cancer cells

3 Aug 2010

Abstract excerpt

BACKGROUND: The miR-200c/141 cluster has recently been implicated in the epithelial to mesenchymal transition (EMT) process. The expression of these two miRNAs is inversely correlated with tumorigenicity and invasiveness in several human cancers. The role of these miRNAs in cancer progression is based in part on their capacity to target the EMT activators ZEB1 and ZEB2, two transcription factors, which in turn...

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PMID: 20682048
DOI: 10.1186/1756-0500-3-219

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