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Article

Loss of DNA methylation is related to increased expression of miR-21 and miR-146b in papillary thyroid carcinoma

20 Nov 2018

Abstract excerpt

BACKGROUND: DNA methylation in miRNA genes has been reported as a mechanism that may cause dysregulation of mature miRNAs and consequently impact the gene expression. This mechanism is largely unstudied in papillary thyroid carcinomas (PTC). METHODS: To identify differentially methylated miRNA-encoding genes, we performed global methylation analysis (Illumina 450 K), integrative analysis (TCGA database), data...

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Share to Epigenetics and DNA Methylation
Share to MicroRNA in disease regulation
Share to Thyroid Cancer Diagnosis and Treatment

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PMID: 30454026
DOI: 10.1186/s13148-018-0579-8

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