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Article

MiR-141 Suppresses the Migration and Invasion of HCC Cells by Targeting Tiam1

13 Feb 2014

Abstract excerpt

BACKGROUND: We have demonstrated that T lymphoma invasion and metastasis 1 (Tiam1) gene is associated with the poor prognosis of patients with hepatocellular carcinoma (HCC), and we used a computational approach to identify miR-141 as a Tiam1-targeting microRNA (miRNA). Here, we explored the function of miR-141 and the relationship between miR-141 and Tiam1 gene in HCC. METHODS: The miR-141 expression in HCC...

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PMID: 24551096
DOI: 10.1371/journal.pone.0088393

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Related research

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Research trail→

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MiR-141 Suppresses the Migration and Invasion of HCC Cells by Targeting Tiam1PMID 24551096Read ↗

MicroRNA-141 inhibits tumor growth and metastasis in gastric cancer by directly targeting transcriptional co-activator with PDZ-binding motif, TAZSemantic proximity Read ↗

Lentivirus-Mediated Silencing of Tiam1 Gene Influences Multiple Functions of a Human Colorectal Cancer Cell LineSemantic proximity Read ↗

MicroRNA-144 inhibits cell proliferation, migration and invasion in human hepatocellular carcinoma by targeting CCNB1Semantic proximity Read ↗

The guanine nucleotide exchange factor Tiam1: A Janus-faced molecule in cellular signalingSemantic proximity Read ↗

Inhibition of long non-coding RNA TUG1 on gastric cancer cell transference and invasion through regulating and controlling the expression of miR-144/c-Met axisSemantic proximity Read ↗

Inhibition of invasion of epithelial cells by Tiam1-Rac signaling.Semantic proximity Read ↗

microRNA-141 inhibits cell proliferation and invasion and promotes apoptosis by targeting hepatocyte nuclear factor-3β in hepatocellular carcinoma cellsSemantic proximity Read ↗

MicroRNA-151 and Its Hosting Gene FAK (Focal Adhesion Kinase) Regulate Tumor Cell Migration and Spreading of Hepatocellular Carcinoma†Semantic proximity Read ↗

MicroRNA-144 suppresses cholangiocarcinoma cell proliferation and invasion through targeting platelet activating factor acetylhydrolase isoform 1bSemantic proximity Read ↗

MicroRNA‐141‐3p regulates cellular proliferation, migration, and invasion in esophageal cancer by targeting tuberous sclerosis complex 1Semantic proximity Read ↗

TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells.Semantic proximity Read ↗

Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinomaSemantic proximity Read ↗

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