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Article

Long non-coding RNA HOTAIR is targeted and regulated by miR-141 in human cancer cells.

The Journal of biological chemistry - 2 May 2014

Chiyomaru Takeshi, Fukuhara Shinichiro, Saini Sharanjot, Majid Shahana, Deng Guoren, Shahryari Varahram, Chang Inik, Tanaka Yuichiro, Enokida Hideki, Nakagawa Masayuki, Dahiya Rajvir, Yamamura Soichiro

Abstract excerpt

HOTAIR is a long non-coding RNA that interacts with the polycomb repressive complex and suppresses its target genes. HOTAIR has also been demonstrated to promote malignancy. MicroRNA-141 (miR-141) has been reported to play a role in the epithelial to mesenchymal transition process, and the expression of miR-141 is inversely correlated with tumorigenicity and invasiveness in several human cancers. We found that...

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Identifiers

PMID: 24616104
DOI: 10.1074/jbc.M113.488593
PMCID: PMC4007447

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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