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Article

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.

Nature cell biology - 1 May 2008

Gregory Philip A, Bert Andrew G, Paterson Emily L, Barry Simon C, Tsykin Anna, Farshid Gelareh, Vadas Mathew A, Khew-Goodall Yeesim, Goodall Gregory J

Abstract excerpt

Epithelial to mesenchymal transition (EMT) facilitates tissue remodelling during embryonic development and is viewed as an essential early step in tumour metastasis. We found that all five members of the microRNA-200 family (miR-200a, miR-200b, miR-200c, miR-141 and miR-429) and miR-205 were markedly downregulated in cells that had undergone EMT in response to transforming growth factor (TGF)-beta or to ectopic...

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Cadherins
Epithelium
Mesoderm
Microarray Analysis
Neoplasm Invasiveness

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transforming Growth Factor beta1

Zinc Finger E-box-Binding Homeobox 1

Zonula Occludens-1 Protein

Source

Identifiers

PMID: 18376396
DOI: 10.1038/ncb1722

Genes

ZEB1
MET
ZEB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.PMID 18376396Read ↗

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ZEB/miR‐200 feedback loop: At the crossroads of signal transduction in cancerSemantic proximity Read ↗

Role of microRNA in epithelial to mesenchymal transition and metastasis and clinical perspectivesSemantic proximity Read ↗

Specificity Protein 1 (Sp1) Maintains Basal Epithelial Expression of the miR-200 FamilySemantic proximity Read ↗

MiR-200 can repress breast cancer metastasis through ZEB1-independent but moesin-dependent pathwaysSemantic proximity Read ↗

Functional Role of the microRNA-200 Family in Breast Morphogenesis and NeoplasiaSemantic proximity Read ↗

miR-1199-5p and Zeb1 function in a double-negative feedback loop potentially coordinating EMT and tumour metastasis.Semantic proximity Read ↗

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAsSemantic proximity Read ↗

Genetic dissection of the miR-200–Zeb1 axis reveals its importance in tumor differentiation and invasionSemantic proximity Read ↗

Zeb1 and Snail1 engage miR-200f transcriptional and epigenetic regulation during EMT.Semantic proximity Read ↗

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