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Article

Epithelial neoplasia in Drosophila entails switch to primitive cell states.

Proceedings of the National Academy of Sciences of the United States of America - 11 Jun 2013

Khan Sumbul J, Bajpai Anjali, Alam Mohammad Atif, Gupta Ram P, Harsh Sneh, Pandey Ravi K, Goel-Bhattacharya Surbhi, Nigam Aditi, Mishra Arati, Sinha Pradip

Abstract excerpt

Only select cell types in an organ display neoplasia when targeted oncogenically. How developmental lineage hierarchies of these cells prefigure their neoplastic propensities is not yet well-understood. Here we show that neoplastic Drosophila epithelial cells reverse their developmental commitments and switch to primitive cell states. In a context of alleviated tissue surveillance, for example, loss of Lethal...

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Identifiers

PMID: 23708122
DOI: 10.1073/pnas.1212513110
PMCID: PMC3683752

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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