Article
Imprinting and the epigenetic asymmetry between parental genomes.
Science (New York, N.Y.) - 10 Aug 2001
Ferguson-Smith A C, Surani M A
Abstract excerpt
Genomic imprinting confers a developmental asymmetry on the parental genomes, through epigenetic modifications in the germ line and embryo. These heritable modifications regulate the monoallelic activity of parental alleles resulting in their functional differences during development. Specific cis-acting regulatory elements associated with imprinted genes carry modifications involving chromatin structural changes...
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