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Article

Genome-wide identification of new imprinted genes.

Briefings in functional genomics - 1 Jul 2010

Henckel Amandine, Arnaud Philippe

Abstract excerpt

In the mid-1980s, elegant studies on mouse embryos revealed that both parental genomes are required for normal development leading to the discovery of genomic imprinting. Imprinting is a parent-of-origin-dependent epigenetic mechanism whereby a subset of autosomal genes is expressed from only one of the parental alleles. Imprinting control involves both DNA- and histone-methylation, which differentially mark the...

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Identifiers

PMID: 20591836
DOI: 10.1093/bfgp/elq016

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