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Article

Drosophila p53 is required to increase the levels of the dKDM4B demethylase after UV-induced DNA damage to demethylate histone H3 lysine 9.

The Journal of biological chemistry - 8 Oct 2010

Palomera-Sanchez Zoraya, Bucio-Mendez Alyeri, Valadez-Graham Viviana, Reynaud Enrique, Zurita Mario

Abstract excerpt

Chromatin undergoes a variety of changes in response to UV-induced DNA damage, including histone acetylation. In human and Drosophila cells, this response is affected by mutations in the tumor suppressor p53. In this work, we report that there is a global decrease in trimethylated Lys-9 in histone H3 (H3K9me3) in salivary gland cells in wild type flies in response to UV irradiation. In contrast, flies with...

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Identifiers

PMID: 20675387
DOI: 10.1074/jbc.M110.128462
PMCID: PMC2951211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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