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Article

Targeted deletion of Rad9 in mouse skin keratinocytes enhances genotoxin-induced tumor development.

Cancer research - 15 Jul 2008

Hu Zhishang, Liu Yuheng, Zhang Chunbo, Zhao Yun, He Wei, Han Lu, Yang Leilei, Hopkins Kevin M, Yang Xiao, Lieberman Howard B, Hang Haiying

Abstract excerpt

The Rad9 gene is evolutionarily conserved from yeast to humans and plays crucial roles in genomic maintenance, DNA repair, and cell cycle checkpoint controls. However, the function of this gene with respect to tumorigenesis is not well-understood. A Rad9-null mutation in mice causes embryonic lethality. In this study, we created mice in which mouse Rad9, Mrad9, was deleted only in keratinocytes to permit...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18632607
DOI: 10.1158/0008-5472.CAN-07-5670
PMCID: PMC4331354

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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