Article
UV sensitive mutations in histone H3 in Saccharomyces cerevisiae that alter specific K79 methylation states genetically act through distinct DNA repair pathways.
Current genetics - 1 May 2008
Evans Margery L, Bostelman Lindsey J, Albrecht Ashley M, Keller Andrew M, Strande Natasha T, Thompson Jeffrey S
Abstract excerpt
Chromatin serves as a regulator of various nuclear processes, with post-translational modifications of histone proteins serving as modulators to influence chromatin function. We have previously shown that histone H3 K79 methylation is important for repair of UV-induced DNA damage in Saccharomyces cerevisiae, acting through multiple repair pathways. To evaluate the potential role of distinct K79 methylation states...
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