Article
Short communication: Nucleotide variation and positively selected sites in HIV type 1 reverse transcriptase among heterosexual transmission pairs.
AIDS research and human retroviruses - 1 Aug 2010
Shanmugasundaram Uma, Solomon Suniti, Murugavel Kailapuri G, Nagalingeswaran Kumarasamy, Solomon Sunil S, Mayer Kenneth H, Pachamuthu Balakrishnan
Abstract excerpt
Mutations in the env gene of HIV-1 have been the primary focus in most epidemiologically related cohort studies of virus evolution and very limited studies have focused on the reverse transcriptase (RT) region, the primary target of antiretroviral therapy (ART). Hence, we measured the selection pressure and searched for the positively selected sites in the RT sequences amplified from HIV-1-infected heterosexual...
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