Article
HIV-I reverse transcriptase variation in plasma and genital secretion of antiretroviral-naive females.
Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) - 1 Jan 2000
Shanmugasundaram Uma, Solomon Suniti, Shanmugam Saravanan, Murugavel Kailapuri G, Nagalingeswaran Kumarasamy, Solomon Sunil S, Mayer Kenneth H, Pachamuthu Balakrishnan
Abstract excerpt
The reverse transcriptase (RT) enzyme of HIV type 1 (HIV-1) is largely targeted by the host immune selection pressure and would differ in the anatomical compartments, thereby having a drastic impact on viral quasi-species evolution. The HIV-1 RT region sequenced from plasma and genital secretions of 8 antiretroviral treatment (ART)-naive females was analyzed for the pattern of amino acid mutations and the ratio...
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