Article
Analysis of selection pressure and mutational pattern of HIV type 1 reverse transcriptase region among treated and nontreated patients.
AIDS research and human retroviruses - 1 Oct 2010
Shanmugasundaram Uma, Solomon Suniti, Madhavan Vidya, Kailapuri Murugavel G, Nagalingeswaran Kumarasamy, Solomon Sunil Suhas, Mayer Kenneth H, Pachamuthu Balakrishnan
Abstract excerpt
Variation of the HIV-1 subtype C reverse transcriptase region (RT) resulting in response to the selective pressures of drug therapy remains poorly characterized. Here, we compared the genetic variation resulting in the presence and absence of antiretroviral drug selective pressures on HIV-1 subtype C RT among nontreated and treated patients. The nucleotide variability, nonsynonymous and synonymous ratio, and the...
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