Article
Intersubtype Genetic Variation of HIV-1 Tat Exon 1.
AIDS research and human retroviruses - 1 Jun 2015
Roy Chandra Nath, Khandaker Irona, Oshitani Hitoshi
Abstract excerpt
HIV-1 Tat is a regulatory protein that plays a pivotal role in viral transcription and replication. Our study aims to investigate the genetic variation of Tat exon 1 in all subtypes of HIV-1: A, B, C, D, F, G, H, J, and K. We performed phylogenetic, mutation, and selection pressure analyses on a total of 1,179 sequences of different subtypes of HIV-1 Tat obtained from the Los Alamos National Laboratory (LANL)....
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