Article
Association of interleukin-1beta (IL1B) polymorphisms with Graves' ophthalmopathy in Taiwan Chinese patients.
Investigative ophthalmology & visual science - 1 Dec 2010
Liu Yu-Huei, Chen Rong-Hsing, Wu Hsin-Hung, Liao Wen-Ling, Chen Wen-Chi, Tsai Yuhsin, Tsai Chang-Hai, Wan Lei, Tsai Fuu-Jen
Abstract excerpt
PURPOSE: To evaluate whether variations in the IL1B gene could be associated with Graves' ophthalmopathy (GO) in patients with Graves' disease (GD). METHOD: This case-control study included 471 Taiwan Chinese patients with GD (200 with GO and 271 without GO) and 160 healthy volunteers. Eight single-nucleotide polymorphisms (SNPs) in IL1B were genotyped with an allele-specific extension and ligation assay....
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