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Article

Predisposition to Graves' disease and Graves' ophthalmopathy by genetic variants of IL2RA.

Journal of molecular medicine (Berlin, Germany) - 1 Oct 2021

Du Juan, Wang Xin, Tan Guiqin, Wei Wenwen, Zhou Fangyu, Liang Zhongzhi, Li Hua, Yu Hongsong

Abstract excerpt

Previous studies have identified that Th17/Treg cells were involved in the occurrence and development of Graves' disease (GD). This study aimed at clarifying the association between GD susceptibility and nine single nucleotide polymorphisms (SNPs) of Th17/Treg cell-related genes, including IL2RA, miR27a, miR182, and FoxO1. A two-stage association study was performed in 650 GD patients and 1300 healthy controls....

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PMID: 34287665
DOI: 10.1007/s00109-021-02111-0

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