Association of the -31C/T functional polymorphism in the interleukin-1beta gene with the intractability of Graves' disease and the proportion of T helper type 17 cells.

doi:10.1111/j.1365-2249.2009.04034.x

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Article

Association of the -31C/T functional polymorphism in the interleukin-1beta gene with the intractability of Graves' disease and the proportion of T helper type 17 cells.

Clinical and experimental immunology - 1 Dec 2009

Hayashi F, Watanabe M, Nanba T, Inoue N, Akamizu T, Iwatani Y

Abstract excerpt

Interleukin (IL)-1beta is a proinflammatory cytokine and has been implicated in the pathogenesis of several autoimmune diseases. To evaluate the hypothesis that the functional -31C/T polymorphism (rs1143627) in the gene encoding IL-1beta is associated with the intractability and the severity of autoimmune thyroid diseases, we genotyped this polymorphism in 64 patients with intractable Graves' disease (GD), 28 GD...

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PMID: 19793334
DOI: 10.1111/j.1365-2249.2009.04034.x
PMCID: PMC2792823

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