Article
The association of interleukin-1alpha and interleukin-1beta polymorphisms with the risk of Graves' disease in a case-control study and meta-analysis.
Human immunology - 1 Apr 2010
Liu Nan, Li Xuejun, Liu Changqin, Zhao Yongju, Cui Bin, Ning Guang
Abstract excerpt
The proinflammatory cytokine interleukin (IL)-1 family has a central role in mediating inflammation and joint destruction in Graves' disease (GD). A number of studies, investigating rs1800587 (IL-1alpha, T-889 C) and rs16944 (IL-1beta, A-511 G) polymorphisms to test their possible association with GD and Graves' ophthalmopathy (GO), had inconsistent results. Our study aims to further evaluate the possible...
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