Article
V-ATPase membrane sector associates with synaptobrevin to modulate neurotransmitter release.
Neuron - 29 Jul 2010
Di Giovanni Jérôme, Boudkkazi Sami, Mochida Sumiko, Bialowas Andrzej, Samari Nada, Lévêque Christian, Youssouf Fahamoe, Brechet Aline, Iborra Cécile, Maulet Yves, Moutot Nicole, Debanne Dominique, Seagar Michael, El Far Oussama
Abstract excerpt
Acidification of synaptic vesicles by the vacuolar proton ATPase is essential for loading with neurotransmitter. Debated findings have suggested that V-ATPase membrane domain (V0) also contributes to Ca(2+)-dependent transmitter release via a direct role in vesicle membrane fusion, but the underl...
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