Article
The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila.
Cell - 20 May 2005
Hiesinger P Robin, Fayyazuddin Amir, Mehta Sunil Q, Rosenmund Tanja, Schulze Karen L, Zhai R Grace, Verstreken Patrik, Cao Yu, Zhou Yi, Kunz Jeannette, Bellen Hugo J
Abstract excerpt
The V(0) complex forms the proteolipid pore of an ATPase that acidifies vesicles. In addition, an independent function in membrane fusion has been proposed largely based on yeast vacuolar fusion experiments. We have isolated mutations in the largest V(0) component vha100-1 in flies in an unbiased genetic screen for synaptic malfunction. The protein is only required in neurons, colocalizes with markers for...
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