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Article

SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release.

Neuron - 1 Dec 1999

Janz R, Goda Y, Geppert M, Missler M, Südhof T C

Abstract excerpt

SV2 proteins are abundant synaptic vesicle proteins expressed in two major (SV2A and SV2B) and one minor isoform (SV2C) that resemble transporter proteins. We now show that SV2B knockout mice are phenotypically normal while SV2A- and SV2A/SV2B double knockout mice exhibit severe seizures and die postnatally. In electrophysiological recordings from cultured hippocampal neurons, SV2A- or SV2B-deficient cells...

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Identifiers

PMID: 10624962
DOI: 10.1016/s0896-6273(00)81046-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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