Article
Evaluation of computational methods for the reconstruction of HLA haplotypes.
Tissue antigens - 1 Dec 2010
Castelli E C, Mendes-Junior C T, Veiga-Castelli L C, Pereira N F, Petzl-Erler M L, Donadi E A
Abstract excerpt
Human leukocyte antigen (HLA) haplotypes are frequently evaluated for population history inferences and association studies. However, the available typing techniques for the main HLA loci usually do not allow the determination of the allele phase and the constitution of a haplotype, which may be obtained by a very time-consuming and expensive family-based segregation study. Without the family-based study,...
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