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Estimation of HLA-A, -B, -DRB1 haplotype frequencies using mixed resolution data from a National Registry with selective retyping of volunteers.

Human immunology - 1 Dec 2007

Kollman Craig, Maiers Martin, Gragert Loren, Müller Carlheinz, Setterholm Michelle, Oudshoorn Machteld, Hurley Carolyn Katovich

Abstract excerpt

Large registries of volunteer hematopoietic stem cell donors typed for HLA contain potentially valuable data for studying haplotype frequencies in the general population. However the usual assumptions for use of the expectation-maximization (EM) algorithm are typically violated in these registries. To avoid this problem, previous studies using registry data have reduced the HLA typings to low-resolution and/or...

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Identifiers

PMID: 18191722
DOI: 10.1016/j.humimm.2007.10.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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