Article
Haplotype inference.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012
Delaneau Olivier, Zagury Jean-François
Abstract excerpt
The information carried by combination of alleles on the same chromosome, called haplotypes, is of crucial interest in several fields of modern genetics as population genetics or association studies. However, this information is usually lost by sequencing and needs, therefore, to be recovered by inference. In this chapter, we give a brief overview on the methods able to tackle this problem and some practical...
Topics
- Algorithms
- Alleles
- Base Sequence
- Computational Biology
- Genetic Loci
- Genetics, Population
- Haplotypes
- Humans
- Linkage Disequilibrium
- Models, Genetic
- Molecular Sequence Data
- Polymorphism, Single Nucleotide