Article
Evaluation of two methods for computational HLA haplotypes inference using a real dataset.
BMC bioinformatics - 29 Jan 2008
Bettencourt Bruno F, Santos Margarida R, Fialho Raquel N, Couto Ana R, Peixoto Maria J, Pinheiro João P, Spínola Hélder, Mora Marian G, Santos Cristina, Brehm António, Bruges-Armas Jácome
Abstract excerpt
BACKGROUND: HLA haplotype analysis has been used in population genetics and in the investigation of disease-susceptibility locus, due to its high polymorphism. Several methods for inferring haplotype genotypic data have been proposed, but it is unclear how accurate each of the methods is or which method is superior. The accuracy of two of the leading methods of computational haplotype...
Topics
- Algorithms
- DNA Mutational Analysis
- HLA Antigens
- Haplotypes
- Humans
- Polymorphism, Single Nucleotide
- Reproducibility of Results
- Sensitivity and Specificity
- Sequence Analysis, DNA