Article
Haplotype reconstruction for diploid populations.
Human heredity - 1 Jan 2005
Zhang Jian, Vingron Martin, Hoehe Margret R
Abstract excerpt
The inference of haplotype pairs directly from unphased genotype data is a key step in the analysis of genetic variation in relation to disease and pharmacogenetically relevant traits. Most popular methods such as Phase and PL do require either the coalescence assumption or the assumption of linkage between the single-nucleotide polymorphisms (SNPs). We have now developed novel approaches that are independent of...
Topics
- Algorithms
- Bayes Theorem
- Computer Simulation
- Diploidy
- Genetic Predisposition to Disease
- Genetic Techniques
- Haplotypes
- Humans
- Monte Carlo Method
- Polymorphism, Single Nucleotide