Comparison of the accuracy of methods of computational haplotype inference using a large empirical dataset.

Abstract excerpt

BACKGROUND: Analyses of genetic data at the level of haplotypes provide increased accuracy and power to infer genotype-phenotype correlations and evolutionary history of a locus. However, empirical determination of haplotypes is expensive and laborious. Therefore, several methods of inferring haplotypes from unphased genotypic data have been proposed, but it is unclear how accurate each of the methods is or which...

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