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Article

Accounting for haplotype phase uncertainty in linkage disequilibrium estimation.

Genetic epidemiology - 1 Feb 2008

Kulle B, Frigessi A, Edvardsen H, Kristensen V, Wojnowski L

Abstract excerpt

The characterization of linkage disequilibrium (LD) is applied in a variety of studies including the identification of molecular determinants of the local recombination rate, the migration and population history of populations, and the role of positive selection in adaptation. LD suffers from the phase uncertainty of the haplotypes used in its calculation, which reflects limitations of the algorithms used for...

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PMID: 17968987
DOI: 10.1002/gepi.20273

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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