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Article

Genetic polymorphisms associated with adverse events and elimination of methotrexate in childhood acute lymphoblastic leukemia and malignant lymphoma.

Journal of human genetics - 1 Jan 2007

Imanishi Hiroyuki, Okamura Noboru, Yagi Mariko, Noro Yukari, Moriya Yuka, Nakamura Tsutomu, Hayakawa Akira, Takeshima Yasuhiro, Sakaeda Toshiyuki, Matsuo Masafumi, Okumura Katsuhiko

Abstract excerpt

Methotrexate is administered in high doses to treat childhood acute lymphoblastic leukemia and malignant lymphoma. Hepatotoxicity and bone marrow suppression often limit its use, however. The objective of this study was to determine the genetic polymorphisms associated with the hepatotoxicity and elimination of methotrexate. Genetic polymorphisms of glutathione S-transferase (GST) genes including GSTT1...

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Topics

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Share to Lymphoma
Share to Antimetabolites, Antineoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutathione S-Transferase pi

Share to Glutathione Transferase

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Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Identifiers

PMID: 17180579
DOI: 10.1007/s10038-006-0096-z

Genes

GSTM1
MTHFR
RFC1
GSTP1
GSTT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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