Article
Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy.
Clinical pharmacology and therapeutics - 1 Jul 2017
Liu Y, Fernandez C A, Smith C, Yang W, Cheng C, Panetta J C, Kornegay N, Liu C, Ramsey L B, Karol S E, Janke L J, Larsen E C, Winick N, Carroll W L, Loh M L, Raetz E A, Hunger S P, Devidas M, Yang J J, Mullighan C G, Zhang J, Evans W E, Jeha S, Pui C-H, Relling M V
Abstract excerpt
Remission induction therapy for acute lymphoblastic leukemia (ALL) includes medications that may cause hepatotoxicity, including asparaginase. We used a genome-wide association study to identify loci associated with elevated alanine transaminase (ALT) levels after induction therapy in children with ALL enrolled on St. Jude Children's Research Hospital (SJCRH) protocols. Germline DNA was genotyped using arrays and...
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