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Article

Pharmacoepigenetics in childhood acute lymphoblastic leukemia: involvement of miRNA polymorphisms in hepatotoxicity.

Epigenomics - 1 Apr 2018

Gutierrez-Camino Angela, Umerez Maitane, Santos Borja, Martin-Guerrero Idoia, García de Andoin Nagore, Sastre Ana, Navajas Aurora, Astigarraga Itziar, Garcia-Orad Africa

Abstract excerpt

AIM: Hepatotoxicity is one of the most common drug-related toxicities during the treatment of childhood acute lymphoblastic leukemia (ALL). Many genes involved in liver-specific signaling pathways are tightly controlled by miRNAs, and miRNA function could be modulated by SNPs. As a consequence, we hypothesized that variants in miRNAs could be associated with drug-induced hepatotoxicity. METHODS: We analyzed 213...

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Share to Antimetabolites, Antineoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29569486
DOI: 10.2217/epi-2017-0138

Genes

DHFR
MTHFR
MTR

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