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Article

Pharmacogenetic considerations for acute lymphoblastic leukemia therapies.

Expert opinion on drug metabolism & toxicology - 1 May 2014

Dulucq Stéphanie, Laverdière Caroline, Sinnett Daniel, Krajinovic Maja

Abstract excerpt

INTRODUCTION: Advances in our understanding of the pathobiology of childhood acute lymphoblastic leukemia (ALL) have led to risk-targeted treatment regimens and remarkable improvement in survival rates. Still, up to 20% of patients experience treatment failure due to drug resistance. Treatment-related toxicities are often life-threatening and are the primary cause of treatment interruption, while ALL survivors...

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Share to Antineoplastic Agents
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Proteins

Share to Pharmacogenetics

Share to Polymorphism, Genetic

Share to Polymorphism, Single Nucleotide

Share to Precision Medicine

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Identifiers

PMID: 24673379
DOI: 10.1517/17425255.2014.893294

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