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Article

Distinct intracellular vesicle transport mechanisms are selectively modified by spastin and spastin mutations.

Journal of cellular physiology - 1 Feb 2011

Fuerst Julia C, Henkel Andreas W, Stroebel Armin, Welzel Oliver, Groemer Teja W, Kornhuber Johannes, Bönsch Dominikus

Abstract excerpt

Spastin is a microtubule severing ATPase that regulates intracellular and axonal transport of vesicles. Intracellular vesicle trafficking was analyzed in differentiated SH-SY5Y-neuroblastoma cells, transfected with spastin wild-type and three spastin mutations (ΔN, K388R, S44L) to investigate spastin-mediated effects on the velocity of vesicles, stained with LysoTracker Red®. The vesicle velocity varied...

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Source

Identifiers

PMID: 20665701
DOI: 10.1002/jcp.22341

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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