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Article

Variants at chromosome 10q26 locus and the expression of HTRA1 in the retina.

Experimental eye research - 1 Jul 2013

Wang Gaofeng, Dubovy Sander R, Kovach Jaclyn L, Schwartz Stephen G, Agarwal Anita, Scott William K, Haines Jonathan L, Pericak-Vance Margaret A

Abstract excerpt

Variations in a locus at chromosome 10q26 are strongly associated with the risk of age-related macular degeneration (AMD). The most significantly associated haplotype includes a nonsynonymous SNP rs10490924 in the exon 1 of ARMS2 and rs11200638 in the promoter region of HTRA1. It is under debate which gene(s), ARMS2, HTRA1 or some other genes are functionally responsible for the genetic association. To verify...

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Source

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Identifiers

PMID: 23644223
DOI: 10.1016/j.exer.2013.04.019
PMCID: PMC4070217

Genes

HTRA1
ARMS2
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Variants at chromosome 10q26 locus and the expression of HTRA1 in the retina.PMID 23644223Read ↗

Age-related macular degeneration-associated variants at chromosome 10q26 do not significantly alter ARMS2 and HTRA1 transcript levels in the human retina.Semantic proximity Read ↗

Risk- and non-risk-associated variants at the 10q26 AMD locus influence ARMS2 mRNA expression but exclude pathogenic effects due to protein deficiency.Semantic proximity Read ↗

Chromosome 10q26-driven age-related macular degeneration is associated with reduced levels of HTRA1 in human retinal pigment epithelium.Semantic proximity Read ↗

Specific correlation between the major chromosome 10q26 haplotype conferring risk for age-related macular degeneration and the expression of HTRA1.Semantic proximity Read ↗

A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration.Semantic proximity Read ↗

Gene Structure of the 10q26 Locus: A Clue to Cracking the ARMS2/HTRA1 Riddle?Semantic proximity Read ↗

Analysis of six genetic risk factors highly associated with AMD in the region surrounding ARMS2 and HTRA1 on chromosome 10, region q26.Semantic proximity Read ↗

rs10490924 surrounding HTRA1/ARMS2 regulates the susceptibility of age-related macular degeneration.Semantic proximity Read ↗

Further mapping of 10q26 supports strong association of HTRA1 polymorphisms with age-related macular degeneration.Semantic proximity Read ↗

10q26 - The enigma in age-related macular degeneration.Semantic proximity Read ↗

LOC387715/HTRA1 gene polymorphisms and susceptibility to age-related macular degeneration: A HuGE review and meta-analysis.Semantic proximity Read ↗

Current Views on Chr10q26 Contribution to Age-Related Macular Degeneration.Semantic proximity Read ↗

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