Article
Characterization of deoxyguanosine-resistant hypoxanthine-guanine phosphoribosyltransferase(-)metastatic variants altered in soybean-agglutinin-binding properties and cell-surface glycoproteins.
Journal of cancer research and clinical oncology - 1 Jan 1991
Damen J E, Spearman M A, Greenberg A H, Wright J A
Abstract excerpt
The isolation of deoxyguanosine-resistant 10T1/2 mouse cell lines following stepwise selection in the presence of increasing concentrations of drug led to the identification of a highly metastatic line, as measured by the ability to form secondary tumors in syngenic mice after intravenous injecti...
Topics
- Animals
- Clone Cells
- Deoxyguanosine
- Drug Resistance
- Hypoxanthine Phosphoribosyltransferase
- Lectins
- Membrane Glycoproteins
- Mice
- Neoplasm Metastasis
- Neoplasms
- Phenotype
- Plant Lectins
- Soybean Proteins
- Transfection
- Tumor Cells, Cultured