Tumor cell surface beta 1-4-linked galactose binds to lectin(s) on microvascular endothelial cells and contributes to organ colonization.

doi:10.1083/jcb.111.2.773

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Article

Tumor cell surface beta 1-4-linked galactose binds to lectin(s) on microvascular endothelial cells and contributes to organ colonization.

The Journal of cell biology - 1 Aug 1990

Cornil I, Kerbel R S, Dennis J W

Abstract excerpt

Cell surface carbohydrate structures acting as ligands for tissue specific mammalian lectins have been implicated in cell-cell interactions during embryogenesis, lymphocyte homing, and tumor cell metastasis. In this report, we provide evidence that beta 1-4 linked galactose (Gal) residues in N-linked oligosaccharides on the surface of blood born tumor cells serve as a ligand for binding to microvascular...

Topics

Alkaloids
Animals
Cattle
Cell Adhesion
Cell Line
Cell Membrane
Endothelium, Vascular
Flow Cytometry
Galactose
Glycoside Hydrolases
Indolizines
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lectins

Lymphoma, Non-Hodgkin

Mice

Mice, Inbred DBA

Mutation

Oligosaccharides

Source

Open in PubMed Open full text

Identifiers

PMID: 2116422
DOI: 10.1083/jcb.111.2.773
PMCID: PMC2116217

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2116422-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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