Article
Sialylation and malignant potential in tumour cell glycosylation mutants.
Glycobiology - 1 Oct 1994
Takano R, Muchmore E, Dennis J W
Abstract excerpt
Somatic mutations and drugs that either reduce beta 1-6GlcNAc-branching of N-linked oligosaccharides or block the addition of terminal sequences containing galactose and sialic acid have been shown to inhibit tumour growth and metastasis. In an attempt to further define the oligosaccharide sequences that contribute to the malignant phenotype, we have selected spontaneous wheat germ agglutinin-resistant (WGAR)...
Topics
- Animals
- Carbohydrate Sequence
- Glycosylation
- Lymphoma
- Mice
- Molecular Sequence Data
- Mutation
- N-Acetylneuraminic Acid
- Neoplasm Metastasis
- Phenotype
- Sialic Acids
- Tumor Cells, Cultured