Article
Genomic binding profiling of the fission yeast stress-activated MAPK Sty1 and the bZIP transcriptional activator Atf1 in response to H2O2.
PloS one - 16 Jul 2010
Eshaghi Majid, Lee Jong Hoon, Zhu Lei, Poon Suk Yean, Li Juntao, Cho Kwang-Hyun, Chu Zhaoqing, Karuturi R Krishna M, Liu Jianhua
Abstract excerpt
BACKGROUND: The evolutionally conserved MAPK Sty1 and bZIP transcriptional activator Atf1 are known to play a pivotal role in response to the reactive oxygen species in S. pombe. However, it is unclear whether all of the H(2)O(2)-induced genes are directly regulated by the Sty1-Atf1 pathway and involved in growth fitness under H(2)O(2)-induced stress conditions. METHODOLOGY/PRINCIPAL FINDINGS: Here we present the...
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