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Article

Peroxide sensors for the fission yeast stress-activated mitogen-activated protein kinase pathway.

Molecular biology of the cell - 1 Feb 2001

Buck V, Quinn J, Soto Pino T, Martin H, Saldanha J, Makino K, Morgan B A, Millar J B

Abstract excerpt

The Schizosaccharomyces pombe stress-activated Sty1p/Spc1p mitogen-activated protein (MAP) kinase regulates gene expression through the Atf1p and Pap1p transcription factors, homologs of human ATF2 and c-Jun, respectively. Mcs4p, a response regulator protein, acts upstream of Sty1p by binding the Wak1p/Wis4p MAP kinase kinase kinase. We show that phosphorylation of Mcs4p on a conserved aspartic acid residue is...

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Source

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Identifiers

PMID: 11179424
DOI: 10.1091/mbc.12.2.407
PMCID: PMC30952

Genes

ATF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Peroxide sensors for the fission yeast stress-activated mitogen-activated protein kinase pathway.PMID 11179424Read ↗

The Atf1 transcription factor is a target for the Sty1 stress-activated MAP kinase pathway in fission yeast.Semantic proximity Read ↗

Cold induces stress-activated protein kinase-mediated response in the fission yeast Schizosaccharomyces pombe.Semantic proximity Read ↗

The Win1 mitotic regulator is a component of the fission yeast stress-activated Sty1 MAPK pathway.Semantic proximity Read ↗

Response regulator-mediated MAPKKK heteromer promotes stress signaling to the Spc1 MAPK in fission yeast.Semantic proximity Read ↗

Deciphering the role of the signal- and Sty1 kinase-dependent phosphorylation of the stress-responsive transcription factor Atf1 on gene activation.Semantic proximity Read ↗

Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1.Semantic proximity Read ↗

Protein phosphatase 2C acts independently of stress-activated kinase cascade to regulate the stress response in fission yeast.Semantic proximity Read ↗

Phospho-mimicking Atf1 mutants bypass the transcription activating function of the MAP kinase Sty1 of fission yeast.Semantic proximity Read ↗

Distinct signaling pathways respond to arsenite and reactive oxygen species in Schizosaccharomyces pombe.Semantic proximity Read ↗

Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast.Semantic proximity Read ↗

A measurable activation of the bZIP transcription factor Atf1 in a fission yeast strain devoid of stress-activated and cell integrity mitogen-activated protein kinase (MAPK) activities.Semantic proximity Read ↗

Genomic binding profiling of the fission yeast stress-activated MAPK Sty1 and the bZIP transcriptional activator Atf1 in response to H2O2.Semantic proximity Read ↗

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