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Article

Deciphering the role of the signal- and Sty1 kinase-dependent phosphorylation of the stress-responsive transcription factor Atf1 on gene activation.

The Journal of biological chemistry - 18 Aug 2017

Salat-Canela Clàudia, Paulo Esther, Sánchez-Mir Laura, Carmona Mercè, Ayté José, Oliva Baldo, Hidalgo Elena

Abstract excerpt

Adaptation to stress triggers the most dramatic shift in gene expression in fission yeast (Schizosaccharomyces pombe), and this response is driven by signaling via the MAPK Sty1. Upon activation, Sty1 accumulates in the nucleus and stimulates expression of hundreds of genes via the nuclear transcription factor Atf1, including expression of atf1 itself. However, the role of stress-induced, Sty1-mediated Atf1...

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PMID: 28652406
DOI: 10.1074/jbc.M117.794339
PMCID: PMC5566521

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Deciphering the role of the signal- and Sty1 kinase-dependent phosphorylation of the stress-responsive transcription factor Atf1 on gene activation.PMID 28652406Read ↗

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