Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of tuberculosis, race, and human gene SLCO1B1 polymorphisms on rifampin concentrations.

Antimicrobial agents and chemotherapy - 1 Oct 2010

Weiner Marc, Peloquin Charles, Burman William, Luo Chi-Cheng, Engle Melissa, Prihoda Thomas J, Mac Kenzie William R, Bliven-Sizemore Erin, Johnson John L, Vernon Andrew

Abstract excerpt

Rifampin has concentration-dependent activity against Mycobacterium tuberculosis. However, marked intersubject variation of rifampin concentrations occurs. In this study, we evaluated rifampin pharmacokinetics in relation to tuberculosis, geographic region, race, and single nucleotide polymorphisms of the human transporter genes SLCO1B1, SLCO1B3, and MDR1. Seventy-two adults with pulmonary tuberculosis from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotics, Antitubercular
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liver-Specific Organic Anion Transporter 1

Share to North America

Share to Organic Anion Transporters

Share to Organic Anion Transporters, Sodium-Independent

Share to Rifampin

Share to Solute Carrier Organic Anion Transporter Family Member 1B3

Source

Open in PubMed Open full text

Identifiers

PMID: 20660695
DOI: 10.1128/AAC.00353-10
PMCID: PMC2944564

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of tuberculosis, race, and human gene SLCO1B1 polymorphisms on rifampin concentrations.PMID 20660695Read ↗

Elevated Plasma Moxifloxacin Concentrations and SLCO1B1 g.-11187G>A Polymorphism in Adults with Pulmonary Tuberculosis.Semantic proximity Read ↗

Genetic Determinants of the Pharmacokinetic Variability of Rifampin in Malawian Adults with Pulmonary Tuberculosis.Semantic proximity Read ↗

Effect of SLCO1B1 Polymorphisms on Rifabutin Pharmacokinetics in African HIV-Infected Patients with Tuberculosis.Semantic proximity Read ↗

Rifampicin population pharmacokinetics and pharmacogenomic evaluation of SLCO1B1 gene in tuberculosis patients.Semantic proximity Read ↗

Relationship among genetic polymorphism of SLCO1B1, rifampicin exposure and clinical outcomes in patients with active pulmonary tuberculosis.Semantic proximity Read ↗

Genetic Diversity in Drug Transporters: Impact in African PopulationsSemantic proximity Read ↗

Decreased plasma rifapentine concentrations associated with AADAC single nucleotide polymorphism in adults with tuberculosis.Semantic proximity Read ↗

The SLCO1B1 rs4149032 polymorphism is highly prevalent in South Africans and is associated with reduced rifampin concentrations: dosing implications.Semantic proximity Read ↗

Role of pharmacogenetics in rifampicin pharmacokinetics and the potential effect on TB-rifampicin sensitivity among Ugandan patients.Semantic proximity Read ↗

Influence of Single Nucleotide Polymorphisms on Rifampin Pharmacokinetics in Tuberculosis PatientsSemantic proximity Read ↗

SLCO1B1 and SLC10A1 polymorphism and plasma rifampin concentrations in patients with co-morbidity tuberculosis-diabetes mellitus in Baja California, Mexico.Semantic proximity Read ↗

Variability in plasma rifampicin concentrations and role of SLCO1B1, ABCB1, AADAC2 and CES2 genotypes in Ethiopian patients with tuberculosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.