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Article

Decreased plasma rifapentine concentrations associated with AADAC single nucleotide polymorphism in adults with tuberculosis.

The Journal of antimicrobial chemotherapy - 11 Feb 2021

Weiner Marc, Gelfond Jon, Johnson-Pais Teresa L, Engle Melissa, Johnson John L, Whitworth William C, Bliven-Sizemore Erin, Nsubuga Pheona, Dorman Susan E, Savic Rada

Abstract excerpt

BACKGROUND: Rifapentine exposure is associated with bactericidal activity against Mycobacterium tuberculosis, but high interindividual variation in plasma concentrations is encountered. OBJECTIVES: To investigate a genomic association with interindividual variation of rifapentine exposure, SNPs of six human genes involving rifamycin metabolism (AADAC, CES2), drug transport (SLCO1B1, SLCO1B3) and gene regulation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33374006
DOI: 10.1093/jac/dkaa490
PMCID: PMC7879139

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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