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Article

Role of pharmacogenetics in rifampicin pharmacokinetics and the potential effect on TB-rifampicin sensitivity among Ugandan patients.

Transactions of the Royal Society of Tropical Medicine and Hygiene - 7 Feb 2020

Mukonzo Jackson K, Kengo Allan, Kutesa Bisaso, Nanzigu Sarah, Pohanka Anton, McHugh Timothy D, Zumla Alimuddin, Aklillu Eleni

Abstract excerpt

BACKGROUND: Suboptimal anti-TB drugs exposure may cause multidrug-resistant TB. The role of African predominant SLCO1B1 variant alleles on rifampicin pharmacokinetics and the subsequent effect on the occurrence of Mycobacterium tuberculosis-rifampicin sensitivity needs to be defined. We describe the rifampicin population pharmacokinetics profile and investigate the relevance of SLCO1B1 genotypes to rifampicin...

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Identifiers

PMID: 31789383
DOI: 10.1093/trstmh/trz108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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