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SLCO1B1 and SLC10A1 polymorphism and plasma rifampin concentrations in patients with co-morbidity tuberculosis-diabetes mellitus in Baja California, Mexico.

Tuberculosis (Edinburgh, Scotland) - 1 Sept 2022

Perea-Jacobo Ricardo, Muñiz-Salazar Raquel, Laniado-Laborín Rafael, Zenteno-Cuevas Roberto, Cabello-Pasini Alejandro, Ochoa-Terán Adrián, Radilla-Chávez Patricia

Abstract excerpt

Rifampicin is one of the most important drugs for the treatment of tuberculosis (TB). Polymorphisms in SLCO1B1 and SLC10A1 genes are associated with impaired transporter function of drug compounds such as rifampicin. The relationship between genetic variation, clinical comorbidities, and rifampicin exposures in TB patients has not been completely elucidated. The aim of this study was to investigate the prevalence...

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PMID: 36055153
DOI: 10.1016/j.tube.2022.102248

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