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Article

Genetic Determinants of the Pharmacokinetic Variability of Rifampin in Malawian Adults with Pulmonary Tuberculosis.

Antimicrobial agents and chemotherapy - 1 Jul 2017

Sloan Derek J, McCallum Andrew D, Schipani Alessandro, Egan Deirdre, Mwandumba Henry C, Ward Steve A, Waterhouse David, Banda Gertrude, Allain Theresa J, Owen Andrew, Khoo Saye H, Davies Geraint R

Abstract excerpt

Variable exposure to antituberculosis (TB) drugs, partially driven by genetic factors, may be associated with poor clinical outcomes. Previous studies have suggested an influence of the SLCO1B1 locus on the plasma area under the concentration-time curve (AUC) of rifampin. We evaluated the contribution of single nucleotide polymorphisms (SNPs) in SLCO1B1 and other candidate genes (AADAC and CES-1) to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28461315
DOI: 10.1128/AAC.00210-17
PMCID: PMC5487625

Genes

AADAC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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