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Article

Elevated Plasma Moxifloxacin Concentrations and SLCO1B1 g.-11187G>A Polymorphism in Adults with Pulmonary Tuberculosis.

Antimicrobial agents and chemotherapy - 1 May 2018

Weiner Marc, Gelfond Jon, Johnson-Pais Teresa L, Engle Melissa, Peloquin Charles A, Johnson John L, Sizemore Erin E, Mac Kenzie William R

Abstract excerpt

Moxifloxacin exhibits concentration-dependent prolongation of human QTc intervals and bactericidal activity against Mycobacterium tuberculosis However, moxifloxacin plasma concentrations are variable between patients. We evaluated whether human gene polymorphisms affect moxifloxacin plasma concentrations in tuberculosis patients from two geographic regions. We enrolled a convenience sample of 49 adults with...

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Identifiers

PMID: 29463526
DOI: 10.1128/AAC.01802-17
PMCID: PMC5923103

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